By JON GAMBRELL, NATALIE MELZER and TIA GOLDENBERG, Associated Press

DUBAI, United Arab Emirates (AP) — Israel unleashed airstrikes across Iran for a third day on Sunday and threatened even greater force as some Iranian missiles evaded Israeli air defenses to strike buildings in the heart of the country. Planned talks on Iran’s nuclear program, which could provide an off-ramp, were canceled.

The region braced for a protracted conflict after Israel’s surprise bombardment of Iran’s nuclear and military sites on Friday killed several top generals and nuclear scientists, and neither side showed any sign of backing down. Iran said Israel struck two oil refineries, raising the prospect of a broader assault on Iran’s heavily sanctioned energy industry that could affect global markets.

The Israeli military, in a social media post, warned Iranians to evacuate arms factories, signaling what could be a further widening of the campaign.

Explosions shook Iran’s capital, Tehran, at around noon and again around 3:30 p.m. Semiofficial news agencies close to Iran’s Revolutionary Guard reported one strike in the area of Vali-e Asr Square downtown and another in a neighborhood named for the air force, which is headquartered there.

U.S. President Donald Trump has expressed full support for Israel’s actions while warning Iran that it can only avoid further destruction by agreeing to a new nuclear deal.

Iranian Foreign Minister Abbas Araghchi said Sunday that if the Israeli strikes on Iran stop, then “our responses will also stop.” He said the United States “is a partner in these attacks and must take responsibility.”

Explosions in Tehran

Iran’s U.N. ambassador said Saturday that 78 people had been killed and more than 320 wounded. There has been no official update since then.

Israel says 13 people have been killed and more than 360 wounded in Iranian attacks. Iran has fired over 270 missiles, 22 of which made impact, according to official Israeli figures. The country’s main international airport and airspace remained closed for a third day.

Israeli strikes targeted Iran’s Defense Ministry early Sunday after hitting air defenses, military bases and sites associated with its nuclear program. The killing of several top generals and nuclear scientists in targeted strikes indicated that Israeli intelligence has penetrated Iran at the highest levels.

In a sign that Iran expects the Israeli strikes to continue, state television reported that metro stations and mosques would be made available as bomb shelters for the public beginning on Sunday night.

Death toll mounts in Israel

In Israel, at least six people, including a 10-year-old and a 9-year-old, were killed when a missile hit an apartment building in Bat Yam, near Tel Aviv. Daniel Hadad, a local police commander, said 180 people were wounded and seven are still missing.

An Associated Press reporter saw streets lined with damaged and destroyed buildings, bombed out cars and shards of glass. Responders used a drone at points to look for survivors. Some people could be seen leaving the area with suitcases.

Another four people, including a 13-year-old, were killed and 24 wounded when a missile struck a building in the Arab town of Tamra in northern Israel. A strike on the central city of Rehovot wounded 42.

The Weizmann Institute of Science, an important center for research in Rehovot, said “there were a number of hits to buildings on the campus.” It said no one was harmed.

Israel has sophisticated multi-tiered air defenses that are able to detect and intercept missiles fired at populated areas or key infrastructure, but officials acknowledge it is imperfect.

Urgent calls to deescalate

World leaders made urgent calls to deescalate. The attack on nuclear sites set a “dangerous precedent,” China’s foreign minister said. The region is already on edge as Israel seeks to annihilate Hamas, an Iranian ally, in the Gaza Strip, where the war is still raging after Hamas’ Oct. 7, 2023, attack.

Prime Minister Benjamin Netanyahu brushed off such calls, saying Israel’s strikes so far are “nothing compared to what they will feel under the sway of our forces in the coming days.”

Israel, the sole though undeclared nuclear-armed state in the Middle East, said it launched the attack to prevent Iran from developing a nuclear weapon. The two countries have been adversaries for decades.

Iran has always said its nuclear program was peaceful, and the U.S. and others have assessed it has not pursued a weapon since 2003. But it has enriched ever larger stockpiles of uranium to near weapons-grade levels in recent years and was believed to have been able to develop multiple weapons within months if it chose to do so. The U.N.’s atomic watchdog censured Iran last week.

Araghchi, Iran’s top diplomat, said Israel had targeted an oil refinery near Tehran and another in a province on the Persian Gulf. He said Iran had targeted “economic” sites in Israel, without elaborating.

Semiofficial Iranian news agencies reported that an Israeli drone strike had caused a “strong explosion” at an Iranian natural gas processing plant. The extent of damage at the South Pars natural gas field was not immediately clear. Such sites have air defense systems around them, which Israel has been targeting.

An oil refinery was also damaged in the northern Israeli city of Haifa, according to the firm operating it, which said no one was wounded.

Iran calls nuclear talks ‘unjustifiable’

A senior U.S. official, speaking on condition of anonymity to discuss the sensitive nuclear talks, said Washington remained committed to them and hoped the Iranians would return to the table.

Araghchi, Iran’s foreign minister, said Saturday that the nuclear talks were “unjustifiable” after Israel’s strikes, which he said were the “result of the direct support by Washington.”

In a post on his Truth Social account early Sunday, Trump reiterated that the U.S. was not involved in the attacks on Iran and warned that any retaliation directed against it would bring an American response “at levels never seen before.”

“However, we can easily get a deal done between Iran and Israel, and end this bloody conflict!!!” he wrote.

‘More than a few weeks’ to repair nuclear facilities

In Iran, satellite photos analyzed by AP show extensive damage at Iran’s main nuclear enrichment facility in Natanz. The images shot Saturday by Planet Labs PBC show multiple buildings damaged or destroyed. The structures hit include buildings identified by experts as supplying power to the facility.

U.N. nuclear chief Rafael Grossi told the Security Council that the above-ground section of the Natanz facility was destroyed. The main centrifuge facility underground did not appear to have been hit, but the loss of power could have damaged infrastructure there, he said.

Israel also struck a nuclear research facility in Isfahan. The International Atomic Energy Agency, the U.N. nuclear watchdog, said four “critical buildings” were damaged, including Isfahan’s uranium conversion facility. The IAEA said there was no sign of increased radiation at Natanz or Isfahan.

An Israeli military official, speaking on condition of anonymity on Sunday in line with official procedures, said it would take “many months, maybe more” to restore the two sites.

Melzer reported from Nahariya, Israel, and Goldenberg from Tel Aviv, Israel. Associated Press writers Nasser Karimi and Amir Vahdat in Tehran, Iran; Sam Mednick and Melanie Lidman in Tel Aviv, Israel, and Julia Frankel in Jerusalem contributed to this report.